Abstract: Nowadays, a wide variety of approaches have been used to improve the less effective traditional wastewater treatment methods. One of the advanced technologies for purifying water is ultrasonic degradation method, which is based on the phenomenon of acoustic cavitation. Semiconductor materials, such as titanium dioxide and zinc oxide, possess large specific surface area, high reactivity, and photo-and sono-sensitive property, making them suitable for execution in wastewater treatment. To find the optimal approach for sewage arrangement, the literatures of the combined use of ultrasonic and semiconductor materials for degradating the pollutants in water were reviewed. The review is aimed at the material type of semiconductor combined with ultrasonic on pollutants degradation and the influence of different experimental parameters on their sonocatalytic activities, such as ultrasonic irradiation time, pollutants concentration, solution temperature, solution pH, sonocatalyst dosage and crystal phases of sonocatalyst, etc. From what has been discussed, it could be concluded that the sonocatalysts consisting of up-conversion luminescent reagent and two different band gap semiconductor materials will have excellent sonocatalytic activities and wide applications for sonocatalytic degradation of organic pollutants, providing a new way to achieve large-scale dispose of wastewater.