Abstract: The national key ecological function zone could be delineated as one type of ecological conservation redline. Mine ecological environment damage is recognized as one of the largest causes of regional ecological security problem. For many years, the exploitation of mineral resources has effectively promoted regional economic and social development, in the meanwhile, caused serious problems in the ecology and environment of mining areas. Distribution of historical mines in the key ecological function zones and their ecology and environment problems were retrospectively analyzed in the Yangtze River Economic Belt, combining the requirements of delineation and supervision of ecological conservation redline, and the main issues of ecological restoration in the mining area were furtherly discussed. In order to make the transition from mine geological disaster control, vegetation restoration/land reclamation, biodiversity reconstruction to regional ecological function restoration, and finally to promote the integrity of ecosystem among mountain, water, forest, farmland, lake and grassland, and the technical support for the improvement of regional ecological security, a series of countermeasures have been put forward to promote the ecological restoration in the mining area. Specifically, the countermeasures include (1) establishing a mechanism for the supervision and assessment of mine ecological restoration covering all elements of the ecological environment, (2) formulating a special plan for the ecological restoration of mine areas, (3) carrying out the mine ecological environment damage assessment and the research and development of ecological function repair technology, (4) and studying and formulating national standards for mine area ecological restoration.