Abstract: Accroding to the pollution problem of environmental persistent pharmaceutical pollutants (EPPPs), the residual levels and distribution characteristics of 22 kinds of environmental persistent pharmaceutical drug contaminants in water and sediments in Tianjin were investigated by solid phase extraction-high-performance liquid chromatography/tandem mass spectrometry. The results display that the detection rate of 19 kinds of EPPPs was 100% in the water samples from sources, and the concentration range and average concentration were 0.21-0.69 and 0.43 μg·L^-1, respectively. As shown in the surface water samples except for kitasamycin (80%), the detection rate for other 21 kinds of EPPPs was all 100%. Moreover, the concentration range of these EPPPs was from 0.52 to 3.88 μg·L^-1 and the average concentration was 1.60 μg·L^-1. Furthermore, 11 kinds of EPPPs were detected completely (100%) in the sediments and the concentration range and average concentration were 0.04-1.10 and 0.52 μg·kg^-1. Among the above results, the EPPPs residue levels of water samples in the Yuqiao reservoir of Jixian county, Jiyunhe of New Binhai section and sediments in the Duliujian river basin of New Binhai section were the highest. Compared with other EPPPs, the concentrations of ciprofloxacin, norfloxacin, fenoprofen in the water and indomethacin, salicylic acid, florfenicol in sediments were high. In summary, EPPPs residues level of water in Tianjin was higher than other regions in China and other countries.