利用多介质环境逸度模型比较典型抗生素磺胺甲唑和恩诺沙星在水产养殖中的环境归趋

doi:10.19741/j.issn.1673-4831.2021.0073

Abstract

Abstract: The antibiotics sulfamethoxazole and enrofloxacin are commonly used in aquaculture in China, but their fates within the culture environment of tilapia are unclear. Based on the "Guidelines for the use of fishery drugs" (NY 5071-2002) and the "Code for the use of enrofloxacin in aquaculture" (SC/T 1083-2007), the distributions of these two drugs within the tilapia culture environment were studied through field culture experiments. The multi-medium environmental fugacity model was used to simulate the behavior and fate of the drugs. The predicted proportional distributions of sulfamethoxazole in the aquaculture water, fish body and sediment were 92.10%, 7.28% and 0.60%, respectively, and for enrofloxacin the proportions were 64.10%, 35.50% and 0.44%, respectively. While the actual measured proportional distributions of sulfamethoxazole in the culture water and fish were 74.87% and 2.66% (muscle 1.03%, liver 1.10%, intestinal content 0.53%), respectively. For enrofloxacin, the fish body accounted for 36.29% (muscle 33.35%, liver 1.62%, intestinal content 1.32%) of the distribution, but enrofloxacin was not detected in either the culture water or sediment samples. The times for sulfamethoxazole levels to decrease to their initial values in the culture water, muscle, liver and intestinal tract[(2.5±0.9) ng·mL^-1 in water, (2.7±0.1) ng·g^-1 in muscle, (37.0±9.3) ng·g^-1 in liver, and (21.5±5.4) ng·g^-1 in intestine] were 32.5, 36.0, 13.1 and 20.4 d respectively. For enrofloxacin, the corresponding elimination times were 5.7 d and 10.3 d for liver and intestine, respectively[liver (4.5±0.3) ng·g^-1, intestinal tract (31.7±2.7) ng·g^-1], but complete elimination did not occur in muscle[initial value of muscle (8.1±2.0) ng·g^-1; residual concentration, (55.7±4.9) ng·g^-1]. It is suggested that the withdrawal periods for sulfamethoxazole and enrofloxacin should not be less than 36 d and 20 d, respectively. These data will be valuable for the protection of the ecological environment of fishery and to ensure the quality and safety of tilapia aquacultural products.

Key words: sulfamethoxazole, enrofloxacin, tilapia, multimedia environment fugacity model, fate

CLC Number:

X592

SHAN Xiang-bao, FANG Long-xiang, SHI Yu-lu, XING Lu-chang, QIU Li-ping, HU Geng-dong, SONG Chao, CHEN Jia-zhang. Comparing the Environmental Fate of Typical Antibiotics Sulfamethoxazole and Enrofloxacin in Aquaculture Using a Multi-media Environmental Fugacity Model[J]. Journal of Ecology and Rural Environment, 2021, 37(8): 1059-1065.

References

[1] 张君.罗非鱼池塘养殖技术[J]. 水产养殖, 2020, 41(10):65-66.
[2] 谢勤莉, 杨辅, 徐德静.罗非鱼养殖技术[J]. 吉林农业, 2016(18):91.
[3] 夏秋博, 卢惠迪, 程广东.罗非鱼常见的细菌性疾病特征与防治[J]. 江西水产科技, 2020(3):31-32.
[4] BIAŁK-BIELIŃSKA A, STOLTE S, ARNING J, et al. Ecotoxicity Evaluation of Selected Sulfonamides[J]. Chemosphere, 2011, 85(6):928-933.
[5] JOHNSON A C, KELLER V, DUMONT E, et al. Assessing the Concentrations and Risks of Toxicity from the Antibiotics Ciprofloxacin, Sulfamethoxazole, Trimethoprim and Erythromycin in European Rivers[J]. Science of the Total Environment, 2015, 511:747-755.
[6] CHEN Y, ZHOU J L, CHENG L, et al. Sediment and Salinity Effects on the Bioaccumulation of Sulfamethoxazole in Zebrafish (Danio rerio)[J]. Chemosphere, 2017, 180:467-475.
[7] 刘仁彬, 姜锦林, 张宇峰, 等. 磺胺甲唑对斑马鱼胚胎/仔鱼的毒性效应[J]. 环境污染与防治, 2020, 42(3):310-316. [LIU Ren-bin, JIANG Jin-lin, ZHANG Yu-feng, et al. Toxic Effects of Sulfamethoxazole on Zebrafish (Danio rerio) Embryo/Larva[J]. Environmental Pollution and Control, 2020, 42(3):310-316.]
[8] 黄铢玉, 方龙香, 宋超, 等. 抗生素恩诺沙星在渔业中的研究进展[J]. 农学学报, 2019, 9(11):57-62. [HUANG Zhu-yu, FANG Long-xiang, SONG Chao, et al. Antibiotic Enrofloxacin in Fishery:A Review[J]. Journal of Agriculture, 2019, 9(11):57-62.]
[9] SARMAH A K, MEYER M T, BOXALL A B A.A Global Perspective on the Use, Sales, Exposure Pathways, Occurrence, Fate and Effects of Veterinary Antibiotics (VAs) in the Environment[J]. Chemosphere, 2006, 65(5):725-759.
[10] KÜMMERER K.Antibiotics in the Aquatic Environment:A Review Part I[J]. Chemosphere, 2009, 75(4):417-434.
[11] 方龙香, 宋超, 范立民, 等. 基于正交实验设计的磺胺甲唑在渔业水体中的消解动态规律[J]. 中国农学通报, 2019, 35(27):146-152. [FANG Long-xiang, SONG Chao, FAN Li-min, et al. Sulfamethoxazole in Aquaculture Water by Orthogonal Experimental Design:Degradation Dynamics[J]. Chinese Agricultural Science Bulletin, 2019, 35(27):146-152.]
[12] 张天闻.连续药饵投喂方式下恩诺沙星及其代谢物环丙沙星在大黄鱼体内的残留消除研究[J]. 渔业研究, 2020, 42(1):29-35. [ZHANG Tian-wen.Residue Elimination of Enrofloxacin and Its Metabolite Ciprofloxacin in Larimichthys crocea at Multiple Dosages[J]. Journal of Fisheries Research, 2020, 42(1):29-35.]
[13] 刘慧慧, 罗晶晶, 宋怿, 等. 恩诺沙星及其代谢物在俄罗斯鲟多组织中的代谢及消除研究[J]. 食品安全质量检测学报, 2019, 10(14):4645-4652. [LIU Hui-hui, LUO Jing-jing, SONG Yi, et al. Metabolic and Elimination Rules of Enoxacin and Its Metabolites in Acipenser gueldenstaedtii[J]. Journal of Food Safety & Quality, 2019, 10(14):4645-4652.]
[14] 张德云, 匡维华, 郑映钦.恩诺沙星在日本鳗鲡体内残留消除规律研究[J]. 水产科学, 2007, 26(4):210-213. [ZHANG De-yun, KUANG Wei-hua, ZHENG Ying-qin.Studies on Elimination of Enrofloxacin Residues and Its Metabolites in Eel tissues[J]. Fisheries Science, 2007, 26(4):210-213.]
[15] 李娜, 李健, 王群.恩诺沙星在养殖大菱鲆体内的残留及消除规律[J]. 渔业科学进展, 2009, 30(2):26-33. [LI Na, LI Jian, WANG Qun.The Residue of Enrofloxacin and Its Elimination in Cultivated Scophthalmus maximus[J]. Progress in Fishery Sciences, 2009, 30(2):26-33.]
[16] 尚琪.恩诺沙星在鲤鱼体内代谢产物的研究[D]. 保定:河北农业大学, 2019. [SHANG Qi.Study on the Metabolites of Enrofloxacin in Carp[D]. Baoding:Hebei Agricultural University, 2019.]
[17] LIU Y T, HAN G, DONG J, et al. Sex-Related Differences in Disposition of Sulfamethoxazole, N-Acetyl-Sulfamethoxazole and Trimethoprim in Yellow Catfish (Pelteobagrus fulvidraco) Following a Single Oral Administration[J]. Aquaculture, 2021, 531:735869.
[18] 黄铢玉, 方龙香, 宋超, 等. 不同温度和pH对恩诺沙星及其代谢产物环丙沙星在渔业下层水体中消除规律的影响[J]. 中国农学通报, 2020, 36(21):132-139. [HUANG Zhu-yu, FANG Long-xiang, SONG Chao, et al. Temperature and pH:Effect on the Elimination Rule of Enrofloxacin and Its Metabolite Ciprofloxacin in Fishery Lower Water Bodies[J]. Chinese Agricultural Science Bulletin, 2020, 36(21):132-139.]
[19] 张石云, 宋超, 张敬卫, 等. 微塑料暴露对罗非鱼肌肉中磺胺甲唑残留的影响[J]. 生态与农村环境学报, 2018, 34(9):857-864. [ZHANG Shi-yun, SONG Chao, ZHANG Jing-wei, et al. Effects of Micro-Plastics on Sulfamethoxazole (SMZ) Residues in Tilapia(Oreochromis niloticus) Muscle[J]. Journal of Ecology and Rural Environment, 2018, 34(9):857-864.]
[20] MACKAY D, PATERSON S.Evaluating the Multimedia Fate of Organic Chemicals:A Level Ⅲ Fugacity Model[J]. Environmental Science & Technology, 1991, 25(3):427-436.
[21] GOUIN T.Modelling the Environmental Fate of the Polybrominated Diphenyl Ethers[J]. Environment International, 2003, 29(6):717-724.
[22] 袁科平, 艾晓辉.磺胺甲唑在罗非鱼体内的药代动力学及组织浓度研究[J]. 水利渔业, 2008, 29(3):25-27.
[23] 王欢, 许荔立, 陈孝煊, 等. 不同温度下恩诺沙星在克氏原螯虾体内的药代动力学[J]. 华中农业大学学报, 2021, 40(1):112-119. [WANG Huan, XU Li-li, CHEN Xiao-xuan, et al. Pharmacokinetics of Enrofloxacin in Procambarus Clarkii at Different Temperatures[J]. Journal of Huazhong Agricultural University, 2021, 40(1):112-119.]
[24] 艾晓辉, 刘长征, 周运涛.不同水温和给药方式下磺胺甲唑在草鱼体内的药动学研究[J]. 水生生物学报, 2005, 29(2):210-214. [AI Xiao-hui, LIU Chang-zheng, ZHOU Yun-tao.A Study on Pharmacokinetic of Sulphamethoxazole in Grass Carp at Different Temperatures and Administration Regimes[J]. Acta Hydrobiologica Sinica, 2005, 29(2):210-214.]
[25] 刘长征, 艾晓辉, 伍刚, 等. 水产品中磺胺甲唑与甲氧苄啶含量的高效液相色谱测定法[J]. 淡水渔业, 2004, 34(2):23-24.
[26] 杨秋红, 艾晓辉, 刘永涛, 等. 不同温度下恩诺沙星及其代谢物在斑点叉尾各组织中的残留及消除规律比较[J]. 水生生物学报, 2017, 41(4):781-786. [YANG Qiu-hong, AI Xiao-hui, LIU Yong-tao, et al. Studies on Elimination Dynamics of Enrofloxacin Residues and Its Metabolites in Channel Catfish at Two Different Water Temperatures[J]. Acta Hydrobiologica Sinica, 2017, 41(4):781-786.]
[27] 李邦平, 孟勇, 朱晓华, 等. 池塘养殖水体与底泥中恩诺沙星降解规律的初步研究[J]. 水产养殖, 2020, 41(1):16-21. [LI Bang-ping, MENG Yong, ZHU Xiao-hua, et al. The Study of Residues of Enrofloxacin and Its Metabolites Ciprofloxacin in Aquaculture Environment[J]. Journal of Aquaculture, 2020, 41(1):16-21.]
[28] 彭刚, 刘伟杰, 童军, 等. 池塘循环水生态养殖效果分析[J]. 水产科学, 2010, 29(11):643-647. [PENG Gang, LIU Wei-jie, TONG Jun, et al. Ecological Aquaculture Analysis in a Recirculating Water Pond[J]. Fisheries Science, 2010, 29(11):643-647.]
[29] 温志良, 张爱军, 温琰茂.集约化淡水养殖对水环境的影响[J]. 水利渔业, 2000, 21(4):19-20.
[30] BENOTTI M J, BROWNAWELL B J.Microbial Degradation of Pharmaceuticals in Estuarine and Coastal Seawater[J]. Environmental Pollution, 2009, 157(3):994-1002.
[31] 任红蕾, 张蓬, 李凯, 等. 水中氟喹诺酮类抗生素光降解过程中抑菌活性的变化[J]. 环境化学, 2014, 33(5):753-759. [REN Hong-lei, ZHANG Peng, LI Kai, et al. Changes in Antibacterial Activity of Fluoroquinolone Antibiotics Due to Photodegradation[J]. Environmental Chemistry, 2014, 33(5):753-759.]
[32] 王洪艳, 李兆新, 邢丽红, 等. 恩诺沙星及其代谢产物环丙沙星在牙鲆体内代谢消除规律[J]. 渔业科学进展, 2014, 35(3):44-49. [WANG Hong-yan, LI Zhao-xin, XING Li-hong, et al. Pharmacokinetics of Enrofloxacin and Its Metabolite Ciprofloxacin in Flounder Paralichthys Olivaceus[J]. Progress in Fishery Sciences, 2014, 35(3):44-49.]
[33] 徐维海, 林黎明, 朱校斌, 等. 恩诺沙星及其代谢产物在吉富罗非鱼、中国对虾体内的残留规律研究[J]. 水产科学, 2004, 23(7):5-8. [XU Wei-hai, LIN Li-ming, ZHU Xiao-bin, et al. Residues of Enrofloxacin and Its Metabolite in Jifu tilapia and Penaeus chinensis[J]. Fisheries Science, 2004, 23(7):5-8.]

Comparing the Environmental Fate of Typical Antibiotics Sulfamethoxazole and Enrofloxacin in Aquaculture Using a Multi-media Environmental Fugacity Model

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 13

Recommended Articles

Metrics

Comments

[1]	WANG Xiao-lei, WU Gen-hua, FANG Guo-dong, ZHOU Dong-mei. Transition Metal Activated Persulfate for Environmental Remediation: A Review [J]. Journal of Ecology and Rural Environment, 2021, 37(2): 145-154.
[2]	LIU Dan, LI Lu, SONG Kang, ZHOU Xiao-hong. FEEM Analysis of Fulvic Acid Pretreatment by Advanced Oxidation Processes. [J]. Journal of Ecology and Rural Environment, 2020, 36(7): 914-920.
[3]	TANG Rong, MAO Su-nan. Preparation of C-Co Derived From Co Prussian Blue Analogues as an Activator of Peroxymonosulfate for the Degradation of Methylene Blue [J]. Journal of Ecology and Rural Environment, 2020, 36(6): 811-818.
[4]	WU Meng-ting, MEI Juan, SU Liang-hu, JI Kai, YAN Cheng, ZHANG Yi. Effects of Ferrous Sulfate and Calcium Superphosphate on Nitrogen Loss and Humification During Co-Composting of Cattle Manure With Straw [J]. Journal of Ecology and Rural Environment, 2020, 36(10): 1353-1361.
[5]	ZHANG Shi-yun, SONG Chao, ZHANG Jing-wei, CHEN Ze-qiu, ZHANG Cong, QIU Li-ping, CHEN Jia-zhang. Effects of Micro-Plastics on Sulfamethoxazole (SMZ) Residues in Tilapia (Oreochromis niloticus) Muscle [J]. Journal of Ecology and Rural Environment, 2018, 34(9): 857-864.
[6]	ZHANG Wei, ZHANG Li-li. Forms of Sulfur and Distribution of Sulfate-Reducing Bacteria in Limestone Soil of Small Karst Catchment [J]. Journal of Ecology and Rural Environment, 2017, 33(7): 645-652.
[7]	SHI Chen-fei, LI Yu-meng, FENG Rui-jie, JIA Shu-min, XUE Rui-jie, WANG Guo-xiang. Preparation of Biochar From Cyanobacteria and Function of the Biochar for Persulfate Activation [J]. Journal of Ecology and Rural Environment, 2017, 33(12): 1140-1145.
[8]	CHEN Jia-Zhang, QIU Li-Ping, QU Jian-Hong, MENG Shun-Long, FAN Li-Min, JIA Xu-Shu, SONG Chao. Effects of Benzo(a)pyrene on Activities of Hepatic CYP1A1 and GST in Tilapia [J]. Journal of Ecology and Rural Environment, 2014, 30(2): 268-272.
[9]	WANG Na, WANG Zan-Chang, GE Feng, XU Jing, SHAN Zheng-Jun. Environmental Exposure Assessment of Three Typical Kinds of Veterinary Antibiotics [J]. Journal of Ecology and Rural Environment, 2014, 30(1): 77-83.
[10]	WANG Shuai, WANG Hong-Qi, WANG Rui-Bin, ZHANG Xin. Fate of Complex Pollutants of Lead and Benzo[a]pyrene in Soil-Plant System [J]. Journal of Ecology and Rural Environment, 2013, 29(6): 723-730.
[11]	LI Fang-Liang, LI Zhong-Pei, LIU Ming, JIANG Chun-Yu. Effects of Application Rate of Ammonium Sulfate and Temperature on Nitrification in and Microbial Properties of Paddy Red Soil [J]. Journal of Ecology and Rural Environment, 2012, 28(4): 410-415.
[12]	ZHANG Chun-Yan, ZHOU Xiao-Zhi, CHEN Ju-Fang, NIE Xiang-Ping. Dynamics and Fate of Ciprofloxacin in a Simulated Aquatic System [J]. Journal of Ecology and Rural Environment, 2009, 25(3): 73-78.
[13]	SHEN Biao, HONG Qing, LI Shun-Peng. LuxAB-Labeling of Methylparathion-Degrading Bacterium Pseudomonas sp.DLL-1 and Its Fate in the Soil [J]. Journal of Ecology and Rural Environment, 2002, 18(1): 16-21.