Abstract: Key ecological function zones are essential to guarantee of national and regional ecological safety. Changes in ecology of the key ecological function zones of China during the years of 2000-2010 were analyzed, using ecological function index, ecological structure index and ecological stress index as indicators. Results show that among the eight key ecological function zones of the water source conserving type, the Greater and Lesser Khingan forest ecological function zone, the Altai mountain forest steppe ecological function zone and the Nanling mountain forest and biodiversity ecological function zone tended to deteriorate in ecological status, while the other five did reversely. The key ecological function zones of the water and soil conservation type all turned better, especially the Loess Plateau hill and gully soil-water conservation ecological function zone. Among the six key ecological function zones of the sand-shifting control type, the Hulunbuir prairie meadow ecological function zone and the Arkin steppe desertification control ecological function zone went towards better in ecology, while the other four did towards worse. And all the key ecological function zone of the biodiversity protection type were getting somewhat better.