Abstract: It is of great significance to explore the spatial-temporal evolution laws of slope cultivated land utilization driven by various factors in karst trough valley area, which can help the regional food security and land management. Based on the high-resolution image and DEM as the data sources combined with field survey to verify the image, the slope cultivated land was calculated by using dynamic index and buffer analysis to study the general laws and differences of spatial-temporal evolution of slope cultivated land. The results are as follows:(1) During the period from 2005 to 2017, the slope cultivated land in the western, middle and eastern trough valley all changed dynamically and the most significant change were the gentle slope cultivated land and oblique slope cultivated land. (2) As the increase of distance between residential and road areas, the change of areas of slope cultivated land showed different decreasing trends. (3) In the western and eastern trough valley, the slope cultivated land transfer mainly focused on the trough basine, while in the middle trough valley mainly focused on the hillsides. (4) The spatial-temporal differentiation pattern of slope cultivated land evolution were affected by various factors, among them, the topography and landform of karst trough valley had a decisive role in the formation of slope cultivated land, the improvement of regional economic output had a transform effect on the slope cultivated land use and agricultural structure adjustment had diversity effect on slope cultivated land use function. Therefore to evaluate, the multi-factors and the evolution trend of slope cultivated land use in trough valley areas can provide scientific reference for regional local policy.