Abstract: Based on the findings of the first national pollution investigation, issues, like arrangement of monitoring postspoints, sampling for monitoring and data analysis in measuring and calculating rural domestic waste generation and discharge coefficients in the Taihu Lake regionbasin were analyzed in depth. By following the principles of taking into consideration of natural environment zoning and economic income grading, and distributing the monitoring points rationally with stress on key points, a total of 15 monitoring points were set up for two categories of farmer households, with and without sewage system in 6 regions different in type. Steps for sampling of rural domestic waste were analyzed specifically and record forms for the sampling were designed to facilitate standardization of data entry, analysis and processing. Monitoring data were processed for mathematic statistics in line with the Grubbs norm and Dixon norm. Abnormal values, like maximum or minimum values, were verified with the Grubbs norm.