Abstract: Biological species resources are kind of strategic resources essential to sustainable development of the national economy. The research and development of a bio-species resources information system is of great significance to rational protection and sustainable utilization of the rich bio-species resources of the country’s, as well as to improvement of the management of national bio-species resources information. In response to the requirements of the nation for protection and management of the bio-species resources and with the aid of the technologies of GIS, information network and database, a GIS-based national bio-species resources information system (NSRIS) was designed and developed, and a national bio-species resources spatial distribution database was built up using county as basic unit. The overall framework of NSRIS consists of four subsystems, that is, platform management, data acquisition and management, data query and statistical analysis, and comprehensive analysis. With this system, users can effectively collect, manage and retrieve wild vascular plants and vertebrates data and information, and make use of its statistical analysis and prediction functions investigation and evaluation of the large-scale national of regional bio-species resources distribution patterns,and their status,future trends and potential threats,and hence provide decision-makers with essential early-warning information for protection and management of the national bio-species resources.To update and upgrade NSRIS, it is essential to strengthen collection and collation of important bio-species resource data from field surveys, and long-term dynamic monitoring, and ocean biodiversity data and information, to build up a mechanism for trans-departmental sharing of bio-species resource information and to develop and integrate bio-species resources predictive and early warning models, so as to form a decision-making support system.