Abstract: More than 200 kinds of organic pollutants were detected in water samples collected from different depths of five monitoring sections in estuary of the Yangtze River in dry and flood seasons.Among the 53 quantitatively measured kinds,36 kinds were in the list of venomous organic compounds specified by EPA of the USA for control,and 16 kinds in the blacklist of China for priority control in environment protection.In the dry season,N-dimethylnitrosamine was the highest in concentration with the maximum value reaching up to 11.2 mg·L^-1,while in the flood season,2,4-dinitrophenol and butylbenzyl phthalate were high in concentration with the highest to be 1.3 and 1.0 mg·L^-1,respectively.The concentration of organic pollutants in the deep water layer was higher than in the surface and middle layers.