Abstract: A new model or method for optimizing land use arrangement is invented based on CLUE-S and Grey linear programming (GLP), and can be used to conduct integrated optimization of quantity structure and spatial distribution of land use, after the data of regional policy social economy, ecological targets and land use status quo are imported into the model. The area of North Jiaxing was selected as a case for study. Three different scenarios, i.e. current trend (A), programmed target (B) and programmed sustainable (C), were simulated. Results show that as Scenario A emphasized social, economic and environmental benefits, its effect of controlling rapid growth of construction land and continuous decrease in farmland was significant. Therefore, Scenario A may provide ecologically sensitive areas with dual protections, environment and food safety, and hence is an ideal optimization programme for land use. The use of CLUE-S model coupled with GLP is an effective solution to the problem of optimal arrangement of land resources, because it can be used to simulate variation of land use in quantity and spatial distribution by taking into account the current situation and development targets of a region simultaneously.