Abstract: A static adsorption experiment on behavior of adsorption of sulfadiazine by montmorillonite and kaolinite was carried out to investigate influence of temperature,and pH on adsorption.Results show that the adsorption isotherms of sulfadiazine on montmorillonite and kaolinite were well described by the Freundlich and Langmuir equations,and the latter is better than the former in fitting.Kaolinite was higher in adsorption capacity than montmorillonite.Adsorption of sulfadiazine decreased with increasing temperature and peaked at pH 8.