Abstract: With the large-scale commercial planting of genetically modified (GM) crops in the world, the gene flow from GM crops to their wild relatives and its environmental risks have become a new topic in the field of biosafety of GMs. Wild soybean is one of the most important biological resources in China. China has not only imported a large number of GM soybeans every year, but also started to carry out field experiments of GM soybeans with intellectual property rights, therefore, the gene flow of GM soybean to its wild relatives and its influence on natural resources are the core problems that must be solved before the commercialized planting of GM soybean in China. The research progress of gene flow from transgenic soybean to wild soybean at home and aboard are reviewed from the aspects of gene flow from GM soybean to its wild relatives and the fitness of hybrid offsprings. In this paper, the research progress of gene flow from GM soybean to wild relatives and the fitness of hybrid offsprings were reviewed. The problems existing in the fitness of hybrid offsprings and the study and the future development trend of gene flow from GM soybean to wild soybean are pointed out.