Abstract: Ecosystem service is the bridge connecting nature and human well-being. To meet mankind's demand, the ecosystem endures to provide products and services through ecological functions. Based on the analysis of global research progress on ecosystem service, human well-being, and their relationships, this study summarizes the associations and classifications of ecosystem services with human well-being and explains relationship forms, and relationship evaluation methods. The study emphasized that the scientific research on the relationship between ecosystem service and human well-being should be intensified and well directed towards serving policy-making and management in future. Through a comprehensive review, it provides a strong support for sustainable development strategies such as ecosystem management, and poverty alleviation.