Abstract: In order to select cadmium pollution remediation materials suitable for slightly alkaline soil, two kinds of amendments including silicon-calcium-magnesium fertilizer and modified humic acid and their complex combination were adopted to conduct pot experiments with farmland Cd contaminated soil. The deactivation efficiency was evaluated via diethylenetriaminepentaacetic acid (DTPA) extraction method and Tessier analysis of soil Cd activity as well as determination of the content in various organs of wheat. The scanning electron microscopy and energy dispersive spectrometer (SEM-EDS) was utilized to explore the surface microscopic morphology and elemental composition of the amendment. Results demonstrate that silicon-calcium-magnesium fertilizer could significantly increase soil pH value, change the chemical form of Cd in soil and reduce the content DTPA extraction Cd. Compared with the control, the Cd content in wheat root was decreased by 73.95% and 97.15% at jointing stage and mature stage, respectively, after the application of silicon-calcium-magnesium fertilizer (3%); and the Cd content in wheat grains was decreased by 86.44% after the application of silicon-calcium-magnesium fertilizer (1.2%). In terms of reducing Cd content in soil DTPA extracted form and Cd content in wheat grains, the effect of modified humic acid was lower than that of the silicon-calcium-magnesium fertilizer. The contents of Cd in wheat treated with 1.2% and 3.0% modified humic acid were decreased by 35.98%-38.01% compared with the control. The content of Cd in wheat grains was decreased by 81.77% after the application of silicon-calcium-magnesium fertilizer and modified humic acid. In conclusion, the combination of silica-calcium-magnesium fertilizer and modified humic acid has the best effect, which can effectively inactivate the activity of Cd in soil and significantly reduce the content of Cd in wheat grains.