Abstract: A systematic introduction is presented to key problems and their countermeasures in screening analysis of persistent organic pollutants (POPs) in environmental samples using EPA 8081A and EPA 8082 methods,covering the double-column system for gas chromatographic analysis and validation of POPs,decomposition of DDT and endrin in the sample injection system and its countermeasures,rapid identification of multi-peaked compounds,such as polychlorinated biphenyl (PCBs),chlordane and toxaphene with empirical methods,such as visual recognition method,chiral method,transparent copy film method,etc.,key factors affecting the accuracy of quantification of multi-peaked POPs,such as PCBs,chlordane and toxaphene with the external standard method and requirements of quality control.It is,therefore,suggested that a library of standard samples and standard chromatographs of POPs be established in light of the characteristics of POPs pollution of the environment of China,so as to provide the survey and environmental monitoring of POPs pollution in China with effective technical support.