双酚A及其类似物对斑马鱼成鱼及胚胎的急性毒性

doi:10.11934/j.issn.1673-4831.2017.04.011

Abstract

Abstract:

Little is known so far about toxicities of bisphenol B(BPB), bisphenol F(BPF), bisphenol AP(BPAP), bisphenol AF(BPAF), bisphenol Z(BPZ), bisphenol P(BPP), bisphenol S (BPS), although they have been used widely as BPA substitutes. A comparative study was done by exposing adults and embryos of zebrafish to the 8 kinds of chemicals for 24, 48, 72 and 96 hours to determine half lethal concentration (LC₅₀) and fatality rate at different time intervals. Results show that the toxicities of bisphenol A and its analogues to adult zebrafish were linearly related to their respective ones to zebrafish embryos. According to the criteria for grading of toxicity in "Rules for Classification and Labeling of Chemicals, Part 28:Hazardous to the Aquatic Environment", BPP is sorted into Grade Ⅰ in toxicity and BPA, BPB, BPF, BPZ, BPAP and BPAF into Grade Ⅱ, while according to the Verhaar classification system, bisphenol A and its analogues belong to the category of chemicals with anesthetic toxication mechanism and degree of their toxicities is related to hydrophobic groups.

Key words: bisphenol A and its analogue, acute toxicity, median lethal concentration (LC₅₀), deformity

CLC Number:

X592

REN Wen-juan, WANG Zhen, YANG Xian-hai, LIU Ji-ning, YANG Qian, CHEN Ying-wen, SHEN Shu-bao. Acute Toxicity Effect of Bisphenol A and Its Analogues on Adult and Embryo of Zebrafish[J]. Journal of Ecology and Rural Environment, 2017, 33(4): 372-378.

References

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Acute Toxicity Effect of Bisphenol A and Its Analogues on Adult and Embryo of Zebrafish

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